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Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration.
Neal, Matthew L; Fleming, Sheila M; Budge, Kevin M; Boyle, Alexa M; Kim, Chunki; Alam, Gelareh; Beier, Eric E; Wu, Long-Jun; Richardson, Jason R.
Affiliation
  • Neal ML; Department of Environmental Health, Robert Stempel School of Public Health and Social Work, Florida International University, Miami, FL, USA.
  • Fleming SM; Department of Pharmaceutical Sciences and Center for Neurodegenerative Disease and Aging, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Budge KM; Department of Pharmaceutical Sciences and Center for Neurodegenerative Disease and Aging, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Boyle AM; Department of Biomedical Sciences, Kent State University, Kent, OH, USA.
  • Kim C; Department of Pharmaceutical Sciences and Center for Neurodegenerative Disease and Aging, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Alam G; Department of Biomedical Sciences, Kent State University, Kent, OH, USA.
  • Beier EE; Department of Environmental Health, Robert Stempel School of Public Health and Social Work, Florida International University, Miami, FL, USA.
  • Wu LJ; Department of Pharmaceutical Sciences and Center for Neurodegenerative Disease and Aging, Northeast Ohio Medical University, Rootstown, OH, USA.
  • Richardson JR; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA.
FASEB J ; 34(1): 1679-1694, 2020 01.
Article in En | MEDLINE | ID: mdl-31914683
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Microglia / Neuroprotective Agents / Cell Proliferation / Dopaminergic Neurons / Anisoles / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Microglia / Neuroprotective Agents / Cell Proliferation / Dopaminergic Neurons / Anisoles / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States