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Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis.
Fan, Yao-Yue; Shi, Shu-Qin; Deng, Guo-Zhen; Liu, Hong-Chun; Xu, Cheng-Hui; Ding, Jian; Wang, Guan-Wu; Yue, Jian-Min.
Affiliation
  • Fan YY; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • Shi SQ; Nano Science and Technology Institute , University of Science and Technology of China , Suzhou , Jiangsu 215123 , People's Republic of China.
  • Deng GZ; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • Liu HC; University of Chinese Academy of Sciences , No.19A Yuquan Road , Beijing 100049 , People's Republic of China.
  • Xu CH; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • Ding J; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • Wang GW; State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road , Shanghai 201203 , People's Republic of China.
  • Yue JM; Nano Science and Technology Institute , University of Science and Technology of China , Suzhou , Jiangsu 215123 , People's Republic of China.
Org Lett ; 22(3): 929-933, 2020 02 07.
Article in En | MEDLINE | ID: mdl-31916776
Crokonoid A (1), a highly rearranged diterpenoid featuring a dual-bridged tricyclo[4.4.1.11,4]dodecane-2,11-dione ring system and its two possible ent-kaurene diterpenoid precursors (2 and 3), was isolated and structurally characterized by solid data from Croton kongensis. Compound 1 exhibited significant cytotoxicity against HL-60 and A-549 cell lines with IC50 values of 1.24 ± 0.56 and 1.92 ± 0.60 µM, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Croton / Diterpenes / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2020 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Croton / Diterpenes / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2020 Document type: Article Country of publication: United States