Molecular Classification of Diffuse Gliomas.
Can J Neurol Sci
; 47(4): 464-473, 2020 07.
Article
in En
| MEDLINE
| ID: mdl-31918786
ABSTRACT
Technological advances in the field of molecular genetics have improved the ability to classify brain tumors into subgroups with distinct clinical features and important therapeutic implications. The World Health Organization's newest update on classification of gliomas (2016) incorporated isocitrate dehydrogenase 1 and 2 mutations, ATRX loss, 1p/19q codeletion status, and TP53 mutations to allow for improved classification of glioblastomas, low-grade and anaplastic gliomas. This paper reviews current advances in the understanding of diffuse glioma classification and the impact of molecular markers and DNA methylation studies on survival of patients with these tumors. We also discuss whether the classification and grading of diffuse gliomas should be based on histological findings, molecular markers, or DNA methylation subgroups in future iterations of the classification system.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Biomarkers, Tumor
/
Glioma
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Can J Neurol Sci
Year:
2020
Document type:
Article
Affiliation country:
Canada