Staphylococcus aureus PSM&#945;3 Cross-&#945; Fibril Polymorphism and Determinants of Cytotoxicity.

Tayeb-Fligelman, Einav; Salinas, Nir; Tabachnikov, Orly; Landau, Meytal

Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity.

Tayeb-Fligelman, Einav; Salinas, Nir; Tabachnikov, Orly; Landau, Meytal.

Affiliation

Tayeb-Fligelman E; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Salinas N; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Tabachnikov O; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Landau M; Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel; Centre for Structural Systems Biology (CSSB), and European Molecular Biology Laboratory (EMBL), Hamburg 22607, Germany. Electronic address: mlandau@technion.ac.il.

Structure ; 28(3): 301-313.e6, 2020 03 03.

Article in En | MEDLINE | ID: mdl-31918959

Subject(s)

Bacterial Toxins/chemistry; Bacterial Toxins/toxicity; Staphylococcus aureus/pathogenicity; T-Lymphocytes/cytology; Amyloid/chemistry; Bacterial Toxins/genetics; Cell Line; Cell Membrane/metabolism; Crystallography, X-Ray; Humans; Models, Molecular; Mutation; Polymorphism, Genetic; Protein Aggregates; Staphylococcus aureus/metabolism; T-Lymphocytes/drug effects; T-Lymphocytes/metabolism

Key words

PSMα3; amyloid; chameleon switch peptide; co-aggregation; cross-α fibrils; cytotoxins; membrane rupturing; structural polymorphism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcus aureus / Bacterial Toxins / T-Lymphocytes Limits: Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2020 Document type: Article Affiliation country: Israel Country of publication: United States

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