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Mycobacterium tuberculosis Decaprenylphosphoryl-ß-d-ribose Oxidase Inhibitors: Expeditious Reconstruction of Suboptimal Hits into a Series with Potent in Vivo Activity.
Borthwick, Jennifer A; Alemparte, Carlos; Wall, Ian; Whitehurst, Benjamin C; Argyrou, Argyrides; Burley, Glenn; de Dios-Anton, Paco; Guijarro, Laura; Monteiro, Maria Candida; Ortega, Fatima; Suckling, Colin J; Pichel, Julia Castro; Cacho, Monica; Young, Robert J.
Affiliation
  • Borthwick JA; Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Alemparte C; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Wall I; Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Whitehurst BC; Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Argyrou A; Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
  • Burley G; Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.
  • de Dios-Anton P; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Guijarro L; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Monteiro MC; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Ortega F; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Suckling CJ; Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, Scotland.
  • Pichel JC; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Cacho M; Global Health R&D, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, 28760 Madrid, Spain.
  • Young RJ; Medicinal Science and Technology, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.
J Med Chem ; 63(5): 2557-2576, 2020 03 12.
Article in En | MEDLINE | ID: mdl-31922409
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Bacterial Proteins / Tuberculosis / Alcohol Oxidoreductases / Enzyme Inhibitors / Mycobacterium tuberculosis / Antitubercular Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
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Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Bacterial Proteins / Tuberculosis / Alcohol Oxidoreductases / Enzyme Inhibitors / Mycobacterium tuberculosis / Antitubercular Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United States