Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis.
Exp Eye Res
; 191: 107922, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31923413
ABSTRACT
Besides apoptosis, necrosis can also occur in a highly regulated and genetically controlled manner, defined as regulated necrosis, which is characterized by a loss of cell membrane integrity and release of cytoplasmic content. Depending on the involvement of its signal pathway, regulated necrosis can be further classified as necroptosis, ferroptosis, pyroptosis and parthanatos. Numerous studies have demonstrated that regulated necrosis is involved in the pathogenesis of many diseases covering almost all organs including the brain, heart, liver, kidney, intestine, blood vessel, eye and skin, particularly myocardial infarction and stroke. Most recently, growing evidence suggests that multiple types of regulated necrosis contribute to the degeneration of retinal ganglion cells, retinal pigment epithelial cells or photoreceptor cells, which are the main pathologic features for glaucoma, age-related macular degeneration or retinitis pigmentosa, respectively. This review focuses on the involvement of necroptosis and ferroptosis in these blinding diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinitis Pigmentosa
/
Glaucoma
/
Blindness
/
Ferroptosis
/
Necroptosis
/
Macular Degeneration
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Eye Res
Year:
2020
Document type:
Article
Affiliation country:
China