Tumor-derived extracellular vesicles and microRNAs: Functional roles, diagnostic, prognostic and therapeutic options.
Cytokine Growth Factor Rev
; 51: 75-83, 2020 02.
Article
in En
| MEDLINE
| ID: mdl-31924512
ABSTRACT
In the last few years cancer research more and more highlighted the importance of cell to cell communication in tumor progression. Among many other functional mechanisms, results evidenced the importance of miRNAs loaded into exosomes and their actions as mediators in intercellular communication, either in the tumor microenvironment or at distant sites. Deregulation of miRNA levels is a prerogative of cancer cells and is reflected in the miRNA cargo of tumor derived exosomes. Thus, learning of circulating miRNA activities add the missing piece we need to understand some unclear aspects of cancer biology. Here we summarized the current knowledge on exosome transfer capabilities between cancer cells and all the cells constituting tumor microenvironment with a particular focus on their miRNA cargos and regulatory functions. The clinical relevance of these molecular aspects is emphasized by numerous cell interactions that ultimately result in normal cell function defeat, relevant to increase tumor malignancy. The quantitative and qualitative evaluation of circulating miRNAs offers new perspective for better diagnosis and prognosis of cancer patients, eventually improving their management.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
MicroRNAs
/
Extracellular Vesicles
/
Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
Limits:
Humans
Language:
En
Journal:
Cytokine Growth Factor Rev
Journal subject:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Year:
2020
Document type:
Article
Affiliation country:
Italy