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Insulin deficiency promotes formation of toxic amyloid-ß42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.
Imamura, Tomohiro; Yanagihara, Yuki T; Ohyagi, Yasumasa; Nakamura, Norimichi; Iinuma, Kyoko M; Yamasaki, Ryo; Asai, Hirohide; Maeda, Masahiro; Murakami, Kazuma; Irie, Kazuhiro; Kira, Jun-Ichi.
Affiliation
  • Imamura T; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tomohiro@neuro.med.kyushu-u.ac.jp.
  • Yanagihara YT; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tyuki@neuro.med.kyushu-u.ac.jp.
  • Ohyagi Y; Department of Neurology and Geriatric Medicine, Graduate School of Medicine, Ehime University, 454 Shitsukawa, Toon, Ehime 791-0295, Japan. Electronic address: ohyagiy@m.ehime-u.ac.jp.
  • Nakamura N; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: norimici@neuro.med.kyushu-u.ac.jp.
  • Iinuma KM; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: motomura@neuro.med.kyushu-u.ac.jp.
  • Yamasaki R; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: ryoya@neuro.med.kyushu-u.ac.jp.
  • Asai H; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: asai@neuro.med.kyushu-u.ac.jp.
  • Maeda M; Immuno-Biological Laboratories Co. Ltd., 1091-1 Naka, Aza-Higashida, Fujioka City, Gunma 370-0005, Japan. Electronic address: do-maeda@ibl-japan.co.jp.
  • Murakami K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. Electronic address: alzkazu@kais.kyoto-u.ac.jp.
  • Irie K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. Electronic address: irie@kais.kyoto-u.ac.jp.
  • Kira JI; Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.
Neurobiol Dis ; 137: 104739, 2020 04.
Article in En | MEDLINE | ID: mdl-31927145
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Tau Proteins / Alzheimer Disease / Cognitive Dysfunction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2020 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Peptides / Tau Proteins / Alzheimer Disease / Cognitive Dysfunction Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2020 Document type: Article Country of publication: United States