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Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.
Swope, Nicole; Chung, Wai Keen; Cao, Mingyan; Motabar, Dana; Liu, Dengfeng; Ahuja, Sanjeev; Handlogten, Michael.
Affiliation
  • Swope N; Department of Chemistry, University of Virginia, Charlottesville, Virginia.
  • Chung WK; Purification Process Sciences, AstraZeneca, Gaithersburg, Maryland.
  • Cao M; Analytical Sciences, AstraZeneca, Gaithersburg, Maryland.
  • Motabar D; Purification Process Sciences, AstraZeneca, Gaithersburg, Maryland.
  • Liu D; Analytical Sciences, AstraZeneca, Gaithersburg, Maryland.
  • Ahuja S; Cell Culture and Fermentation Sciences, AstraZeneca, Gaithersburg, Maryland.
  • Handlogten M; Cell Culture and Fermentation Sciences, AstraZeneca, Gaithersburg, Maryland.
Biotechnol Bioeng ; 117(4): 1063-1071, 2020 04.
Article in En | MEDLINE | ID: mdl-31930476
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Recombinant Proteins / Antibodies, Bispecific / Disulfides Limits: Animals Language: En Journal: Biotechnol Bioeng Year: 2020 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Recombinant Proteins / Antibodies, Bispecific / Disulfides Limits: Animals Language: En Journal: Biotechnol Bioeng Year: 2020 Document type: Article Country of publication: United States