Your browser doesn't support javascript.
loading
Mcl-1 inhibits Mff-mediated mitochondrial fragmentation and apoptosis.
Liu, Yangpei; Ma, Yunyun; Tu, Zhuang; Zhang, Chenshuang; Du, Mengyan; Wang, Yong; Yang, Fangfang; Wang, Xiaoping; Chen, Tongsheng.
Affiliation
  • Liu Y; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China; School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China. Electronic
  • Ma Y; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: 15521213054@163.com.
  • Tu Z; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: tuzhuang94@126.com.
  • Zhang C; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: 18373188014@163.com.
  • Du M; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: 15521258581@163.com.
  • Wang Y; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: m13696620651_1@163.com.
  • Yang F; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: 15626456840@163.com.
  • Wang X; Department of Pain Management, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. Electronic address: txp2938@jnu.edu.cn.
  • Chen T; MOE Key Laboratory & Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China. Electronic address: chentsh@scnu.edu.cn.
Biochem Biophys Res Commun ; 523(3): 620-626, 2020 03 12.
Article in En | MEDLINE | ID: mdl-31941601
ABSTRACT
Myeloid cell leukemia-1 (Mcl-1) is involved in the regulation of mitochondrial fission and fusion. This report aims to explore whether Mcl-1 can interact with mitochondrial fission factor (Mff) and regulate Mff-mediated mitochondrial fragmentation and apoptosis. Fluorescence images of living cells coexpressing YFP-Mff and CFP-Mcl-1 showed that Mcl-1 markedly inhibited Mff-mediated mitochondrial fragmentation and apoptosis, suggesting that Mcl-1 played a key role in inhibiting mitochondrial fission. The cells coexpressing YFP-Mff and CFP-Mcl-1 exhibited consistent fluorescence resonance energy transfer (FRET) efficiency with that of the cells coexpressing CFP-Mcl-1 and YFP, demonstrating that Mcl-1 did not directly bind to Mff on mitochondria. Collectively, Mcl-1 inhibits Mff-mediated mitochondrial fission and apoptosis not via directly binding to Mff on mitochondria.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Mitochondrial Proteins / Mitochondrial Dynamics / Myeloid Cell Leukemia Sequence 1 Protein / Membrane Proteins Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Mitochondrial Proteins / Mitochondrial Dynamics / Myeloid Cell Leukemia Sequence 1 Protein / Membrane Proteins Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article