Characterization of Effectiveness in Concerted Ih Inhibition and IK(Ca) Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4'-hydroxystilbene), a Stilbenoid.

So, Edmund Cheung; Gao, Zi-Han; Ko, Shun Yao; Wu, Sheng-Nan

Characterization of Effectiveness in Concerted I_h Inhibition and I_K(Ca) Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4'-hydroxystilbene), a Stilbenoid.

So, Edmund Cheung; Gao, Zi-Han; Ko, Shun Yao; Wu, Sheng-Nan.

Affiliation

So EC; Department of Anesthesia and Medical Research, An Nan Hospital, China Medical University, Tainan 70965, Taiwan.
Gao ZH; Graduate Institute of Medical Sciences, Chang Jung Christian University, Tainan 71101, Taiwan.
Ko SY; Department of Physiology, National Cheng Kung University Medical College, No. 1, University Road, Tainan 70101, Taiwan.
Wu SN; Graduate Institute of Medical Sciences, Chang Jung Christian University, Tainan 71101, Taiwan.

Int J Mol Sci ; 21(1)2020 Jan 05.

Article in En | MEDLINE | ID: mdl-31948124

Subject(s)

Membrane Potentials/drug effects; Neurons/drug effects; Stilbenes/pharmacology; Animals; Calcium/metabolism; Cell Line; Cell Line, Tumor; Cell Polarity/drug effects; Cell Polarity/physiology; Hippocampus/cytology; Hippocampus/drug effects; Hippocampus/metabolism; Hippocampus/physiology; Ion Transport/drug effects; Ion Transport/physiology; Membrane Potentials/physiology; Mice; Neurons/chemistry; Neurons/metabolism; Neurons/physiology; Patch-Clamp Techniques; Pituitary Gland/drug effects; Pituitary Gland/physiology; Potassium Channels/drug effects; Potassium Channels/physiology; Rats

Key words

Ca2+-activated K+ current; Pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene); hippocampal neuron; hyperpolarization-activated cation current; large-conductance Ca2+-activated K+ channel; pituitary cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stilbenes / Membrane Potentials / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article Affiliation country: Taiwan Country of publication: Switzerland

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