Design of Organo-Peptides As Bipartite PCSK9 Antagonists.

Burdick, Daniel J; Skelton, Nicholas J; Ultsch, Mark; Beresini, Maureen H; Eigenbrot, Charles; Li, Wei; Zhang, Yingnan; Nguyen, Huy; Kong-Beltran, Monica; Quinn, John G; Kirchhofer, Daniel

Burdick, Daniel J; Skelton, Nicholas J; Ultsch, Mark; Beresini, Maureen H; Eigenbrot, Charles; Li, Wei; Zhang, Yingnan; Nguyen, Huy; Kong-Beltran, Monica; Quinn, John G; Kirchhofer, Daniel.

ACS Chem Biol ; 15(2): 425-436, 2020 02 21.

Article in En | MEDLINE | ID: mdl-31962046

Subject(s)

PCSK9 Inhibitors; Peptides/pharmacology; Serine Proteinase Inhibitors/pharmacology; Binding Sites; Crystallography, X-Ray; Drug Design; Hep G2 Cells; Humans; Molecular Structure; Peptides/chemistry; Peptides/metabolism; Proprotein Convertase 9/chemistry; Proprotein Convertase 9/metabolism; Protein Binding; Serine Proteinase Inhibitors/chemistry; Serine Proteinase Inhibitors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Serine Proteinase Inhibitors / PCSK9 Inhibitors Limits: Humans Language: En Journal: ACS Chem Biol Year: 2020 Document type: Article Country of publication: United States

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