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TGFß2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells.
Corbet, Cyril; Bastien, Estelle; Santiago de Jesus, Joao Pedro; Dierge, Emeline; Martherus, Ruben; Vander Linden, Catherine; Doix, Bastien; Degavre, Charline; Guilbaud, Céline; Petit, Laurenne; Michiels, Carine; Dessy, Chantal; Larondelle, Yvan; Feron, Olivier.
Affiliation
  • Corbet C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium. cyril.corbet@uclouvain.be.
  • Bastien E; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Santiago de Jesus JP; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Dierge E; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Martherus R; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Vander Linden C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Doix B; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Degavre C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Guilbaud C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Petit L; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Michiels C; Laboratory of Cellular and Molecular Biology (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 61 rue de Bruxelles, B-5000, Namur, Belgium.
  • Dessy C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium.
  • Larondelle Y; Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 2/L7.05.01, B-1348, Louvain-la-Neuve, Belgium.
  • Feron O; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 57 Avenue Hippocrate B1.57.04, B-1200, Brussels, Belgium. olivier.feron@uclouvain.be.
Nat Commun ; 11(1): 454, 2020 01 23.
Article in En | MEDLINE | ID: mdl-31974393
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta2 / Epithelial-Mesenchymal Transition / Lipid Droplets Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Belgium Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta2 / Epithelial-Mesenchymal Transition / Lipid Droplets Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Belgium Country of publication: United kingdom