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The SGLT2 inhibitor empagliflozin reduces mortality and prevents progression in experimental pulmonary hypertension.
Chowdhury, Biswajit; Luu, Albert Z; Luu, Vincent Z; Kabir, M Golam; Pan, Yi; Teoh, Hwee; Quan, Adrian; Sabongui, Sandra; Al-Omran, Mohammed; Bhatt, Deepak L; Mazer, C David; Connelly, Kim A; Verma, Subodh; Hess, David A.
Affiliation
  • Chowdhury B; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada.
  • Luu AZ; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Luu VZ; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
  • Kabir MG; Division of Cardiology, St. Michael's Hospital, Toronto, ON, Canada.
  • Pan Y; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada.
  • Teoh H; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada; Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, ON, Canada.
  • Quan A; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada.
  • Sabongui S; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada.
  • Al-Omran M; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Division of Vascular Surgery, St. Michael's Hospital, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Bhatt DL; Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA, USA.
  • Mazer CD; Department of Anesthesia, St. Michael's Hospital, Toronto, ON, Canada; Department of Anesthesia, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada.
  • Connelly KA; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.
  • Verma S; Division of Cardiac Surgery, St. Michael's Hospital, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada. Electronic address: Subodh.Verma@unityhealth.to.
  • Hess DA; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Division of Vascular Surgery, St. Michael's Hospital, Toronto, ON, Canada; Molecular Medicine Research Laboratories, Robarts Research Institute, London, ON, Canada; Department of Physiology and Pharmacology, Weste
Biochem Biophys Res Commun ; 524(1): 50-56, 2020 03 26.
Article in En | MEDLINE | ID: mdl-31980166

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzhydryl Compounds / Hypertrophy, Right Ventricular / Sodium-Glucose Transporter 2 Inhibitors / Pulmonary Arterial Hypertension / Glucosides Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Affiliation country: Canada Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzhydryl Compounds / Hypertrophy, Right Ventricular / Sodium-Glucose Transporter 2 Inhibitors / Pulmonary Arterial Hypertension / Glucosides Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biochem Biophys Res Commun Year: 2020 Document type: Article Affiliation country: Canada Country of publication: United States