Hypoxic environment may enhance migration/penetration of endocrine resistant MCF7- derived breast cancer cells through monolayers of other non-invasive cancer cells in vitro.

Barrak, Nora H; Khajah, Maitham A; Luqmani, Yunus A

Barrak, Nora H; Khajah, Maitham A; Luqmani, Yunus A.

Affiliation

Barrak NH; Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait.
Khajah MA; Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait.
Luqmani YA; Faculty of Pharmacy, Kuwait University, Safat, 13110, Kuwait. yunus@hsc.edu.kw.

Sci Rep ; 10(1): 1127, 2020 01 24.

Article in En | MEDLINE | ID: mdl-31980706

Subject(s)

Cell Hypoxia; Epithelial-Mesenchymal Transition; MCF-7 Cells/physiology; Basement Membrane; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Movement; Cobalt/pharmacology; Coculture Techniques; Deferoxamine/pharmacology; Estrogens; Female; Gene Expression Regulation, Neoplastic/drug effects; Gene Silencing; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; MCF-7 Cells/drug effects; Neoplasm Invasiveness; Neoplasm Proteins/biosynthesis; Neoplasm Proteins/genetics; Neoplasms, Hormone-Dependent; RNA, Small Interfering/genetics; RNA, Small Interfering/pharmacology; Receptors, Estrogen/analysis; Sepharose

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Hypoxia / Epithelial-Mesenchymal Transition / MCF-7 Cells Limits: Female / Humans Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Kuwait Country of publication: United kingdom

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