Steroidal saponins from Trillium tschonoskii rhizomes and their cytotoxicity against HepG2 cells.
Steroids
; 156: 108587, 2020 04.
Article
in En
| MEDLINE
| ID: mdl-31982423
ABSTRACT
A phytochemical study on the rhizomes of Trillium tschonoskii led to the isolation of fourteen new steroidal saponins, trillitschosides S1-S14 (1-14), along with ten known analogues (15-24). Their structures were established mainly by spectroscopic analyses as well as necessary chemical evidence. All isolated compounds were screened for the cytotoxicity against HepG2 cells, and the results demonstrated that only the known compounds 21-24 exhibited the remarkable cytotoxic activity against HepG2 cells which is much better than the positive control of 5-FU.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Saponins
/
Steroids
/
Plant Extracts
/
Trillium
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Steroids
Year:
2020
Document type:
Article
Affiliation country:
China