Time-to-Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia.

Lohmer, Lauren L; Schippers, Frank; Petersen, Karl Uwe; Stoehr, Thomas; Schmith, Virginia D

Lohmer, Lauren L; Schippers, Frank; Petersen, Karl Uwe; Stoehr, Thomas; Schmith, Virginia D.

Affiliation

Lohmer LL; Nuventra Pharma Sciences, Inc., Durham, North Carolina, USA.
Schippers F; Paion Deutschland GmbH, Aachen, Germany.
Petersen KU; Paion Deutschland GmbH, Aachen, Germany.
Stoehr T; Paion Deutschland GmbH, Aachen, Germany.
Schmith VD; Nuventra Pharma Sciences, Inc., Durham, North Carolina, USA.

J Clin Pharmacol ; 60(4): 505-514, 2020 04.

Article in En | MEDLINE | ID: mdl-31989598

Subject(s)

Benzodiazepines/pharmacokinetics; Hypnotics and Sedatives/pharmacokinetics; Adult; Aged; Anesthesia, General/methods; Benzodiazepines/administration & dosage; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Hypnotics and Sedatives/administration & dosage; Kaplan-Meier Estimate; Linear Models; Middle Aged; Models, Biological; Probability; Time

Key words

anesthesia; dose-response; remimazolam; sedation; time-to-event analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / Hypnotics and Sedatives Type of study: Guideline / Prognostic_studies Limits: Adult / Aged / Humans / Middle aged Language: En Journal: J Clin Pharmacol Year: 2020 Document type: Article Affiliation country: United States Country of publication: United kingdom

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