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Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH.
Hernandez, Gabriella V; Smith, Victoria A; Melnyk, Megan; Burd, Matthew A; Sprayberry, Kimberly A; Edwards, Mark S; Peterson, Daniel G; Bennet, Darin C; Fanter, Rob K; Columbus, Daniel A; Steibel, Juan P; Glanz, Hunter; Immoos, Chad; Rice, Margaret S; Santiago-Rodriguez, Tasha M; Blank, Jason; VanderKelen, Jennifer J; Kitts, Christopher L; Piccolo, Brian D; La Frano, Michael R; Burrin, Douglas G; Maj, Magdalena; Manjarin, Rodrigo.
Affiliation
  • Hernandez GV; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Smith VA; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Melnyk M; Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, California.
  • Burd MA; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Sprayberry KA; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Edwards MS; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Peterson DG; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Bennet DC; Department of Animal Science, California Polytechnic State University, San Luis Obispo, California.
  • Fanter RK; Center for Health Research, California Polytechnic State University, San Luis Obispo, California.
  • Columbus DA; Prairie Swine Centre, Inc., Saskatoon, Saskatchewan, Canada.
  • Steibel JP; Department of Animal Science and Department of Fisheries and Wildlife, Michigan State University, East Lansing, Michigan.
  • Glanz H; Department of Statistics, California Polytechnic State University, San Luis Obispo, California.
  • Immoos C; Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, California.
  • Rice MS; Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, California.
  • Santiago-Rodriguez TM; Diversigen, Inc., Houston, Texas.
  • Blank J; Department of Biological Sciences, California Polytechnic State University, San Luis Obispo, California.
  • VanderKelen JJ; Center for Applications in Biotechnology, California Polytechnic State University, San Luis Obispo, California.
  • Kitts CL; Center for Applications in Biotechnology, California Polytechnic State University, San Luis Obispo, California.
  • Piccolo BD; United States Department of Agriculture-Agricultural Research Services, Arkansas Children's Nutrition Center, Little Rock, Arkansas.
  • La Frano MR; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
  • Burrin DG; Department of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo, California.
  • Maj M; Center for Health Research, California Polytechnic State University, San Luis Obispo, California.
  • Manjarin R; United States Department of Agriculture-Agricultural Research Services, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Am J Physiol Gastrointest Liver Physiol ; 318(3): G582-G609, 2020 03 01.
Article in En | MEDLINE | ID: mdl-32003601
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / Choline / Receptors, Cytoplasmic and Nuclear / Colon / Fibroblast Growth Factors / Non-alcoholic Fatty Liver Disease / Gastrointestinal Microbiome / Liver Type of study: Guideline / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2020 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / Choline / Receptors, Cytoplasmic and Nuclear / Colon / Fibroblast Growth Factors / Non-alcoholic Fatty Liver Disease / Gastrointestinal Microbiome / Liver Type of study: Guideline / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2020 Document type: Article Country of publication: United States