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Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation.
Angelidou, Asimenia; Conti, Maria-Giulia; Diray-Arce, Joann; Benn, Christine S; Shann, Frank; Netea, Mihai G; Liu, Mark; Potluri, Lakshmi Prasad; Sanchez-Schmitz, Guzman; Husson, Robert; Ozonoff, Al; Kampmann, Beate; van Haren, Simon Daniël; Levy, Ofer.
Affiliation
  • Angelidou A; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, M
  • Conti MG; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Sapienza University of Rome, Rome 00185, Italy. Electronic address: MariaGiulia.Conti@childrens.harvard.edu.
  • Diray-Arce J; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Joann.Arce@childrens.harvard.edu.
  • Benn CS; OPEN, Odense Patient Data Explorative Network, Odense University Hospital/Institute of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark. Electronic address: CB@ssi.dk.
  • Shann F; Department of Pediatrics, Royal Children's Hospital, University of Melbourne, Victoria 3052 Australia. Electronic address: shannf@netspace.net.au.
  • Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany. Electronic address: Mihai.Netea@
  • Liu M; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Potluri LP; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: LakshmiPrasad.Potluri@childrens.harvard.edu.
  • Sanchez-Schmitz G; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Guzman.Sanchez-Schmitz@childrens.harvard.edu.
  • Husson R; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Robert.Husson@childrens.harvard.edu.
  • Ozonoff A; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Al.Ozonoff@childrens.harvard.edu.
  • Kampmann B; Vaccine Centre, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK; Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, PO Box 273, Banjul,
  • van Haren SD; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: Simon.VanHaren@childrens.harvard.edu.
  • Levy O; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA. Electronic address: Ofer.Le
Vaccine ; 38(9): 2229-2240, 2020 02 24.
Article in En | MEDLINE | ID: mdl-32005538
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Bacterial / BCG Vaccine / Microbial Viability / Immunogenicity, Vaccine Limits: Adult / Humans / Newborn Country/Region as subject: America do norte / Asia / Europa Language: En Journal: Vaccine Year: 2020 Document type: Article Country of publication: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Bacterial / BCG Vaccine / Microbial Viability / Immunogenicity, Vaccine Limits: Adult / Humans / Newborn Country/Region as subject: America do norte / Asia / Europa Language: En Journal: Vaccine Year: 2020 Document type: Article Country of publication: Netherlands