Pharmacokinetics and Organ Distribution of C-3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid.

Strydom, Natasha; Kaur, Gurminder; Dziwornu, Godwin Akpeko; Okombo, John; Wiesner, Lubbe; Chibale, Kelly

Strydom, Natasha; Kaur, Gurminder; Dziwornu, Godwin Akpeko; Okombo, John; Wiesner, Lubbe; Chibale, Kelly.

Affiliation

Wiesner L; Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

ACS Infect Dis ; 6(3): 459-466, 2020 03 13.

Article in En | MEDLINE | ID: mdl-32011859

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Esters/pharmacokinetics; Fusidic Acid/pharmacokinetics; Prodrugs/pharmacokinetics; Alkylation; Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL

Key words

drug discovery; metabolism; pharmacokinetics; prodrugs; translation; tuberculosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Esters / Fusidic Acid / Anti-Bacterial Agents Limits: Animals Language: En Journal: ACS Infect Dis Year: 2020 Document type: Article Country of publication: United States

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