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WNT/ß-catenin signal inhibitor IC-2-derived small-molecule compounds suppress TGF-ß1-induced fibrogenic response of renal epithelial cells by inhibiting SMAD2/3 signalling.
Hoi, Shotaro; Tsuchiya, Hiroyuki; Itaba, Noriko; Suzuki, Kyosuke; Oka, Hiroyuki; Morimoto, Minoru; Takata, Tomoaki; Isomoto, Hajime; Shiota, Goshi.
Affiliation
  • Hoi S; Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan.
  • Tsuchiya H; Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Itaba N; Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan.
  • Suzuki K; Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan.
  • Oka H; Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, Yonago, Japan.
  • Morimoto M; Research Center for Bioscience and Technology, Tottori University, Tottori, Japan.
  • Takata T; Research Center for Bioscience and Technology, Tottori University, Tottori, Japan.
  • Isomoto H; Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan.
  • Shiota G; Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Japan.
Clin Exp Pharmacol Physiol ; 47(6): 940-946, 2020 06.
Article in En | MEDLINE | ID: mdl-32012313
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protective Agents / Epithelial Cells / Smad2 Protein / Smad3 Protein / Transforming Growth Factor beta1 / Wnt Signaling Pathway / Kidney Diseases / Kidney Tubules Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Clin Exp Pharmacol Physiol Year: 2020 Document type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protective Agents / Epithelial Cells / Smad2 Protein / Smad3 Protein / Transforming Growth Factor beta1 / Wnt Signaling Pathway / Kidney Diseases / Kidney Tubules Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Clin Exp Pharmacol Physiol Year: 2020 Document type: Article Affiliation country: Japan