Less invasive surfactant administration: a word of caution.
Lancet Child Adolesc Health
; 4(4): 331-340, 2020 04.
Article
in En
| MEDLINE
| ID: mdl-32014122
ABSTRACT
Surfactant is a cornerstone of neonatal critical care, and the presumed less (or minimally) invasive techniques for its administration have been proposed to reduce invasiveness of neonatal critical care interventions. These techniques are generally known as less invasive surfactant administration (LISA) and have quickly gained popularity in some neonatal intensive care units. Despite the increase in the use of LISA, we believe that the pathobiological background supporting its possible clinical benefits is unclear. Similarly, it is unclear whether there are any ignored drawbacks, as LISA has been tested in only a few trials and some physiopathological issues seem to have gone unnoticed. Active research is warranted to fill these knowledge gaps before LISA can be firmly recommended. In this Viewpoint, we provide an in-depth analysis of LISA techniques, based on physiological and pathobiological factors, followed by a critical appraisal of available clinical data, and highlight some possible future research directions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome, Newborn
/
Pulmonary Surfactants
/
Intensive Care, Neonatal
/
Lung Diseases, Interstitial
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Humans
/
Newborn
Language:
En
Journal:
Lancet Child Adolesc Health
Year:
2020
Document type:
Article