Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation.

Holmes, Autumn C; Zagnoli-Vieira, Guido; Caldecott, Keith W; Semler, Bert L

Holmes, Autumn C; Zagnoli-Vieira, Guido; Caldecott, Keith W; Semler, Bert L.

Affiliation

Holmes AC; Department of Microbiology & Molecular Genetics and Center for Virus Research, University of California, Irvine, CA 92697, USA.
Zagnoli-Vieira G; Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.
Caldecott KW; Genome Damage and Stability Centre, University of Sussex, Falmer, Brighton BN1 9RQ, UK.
Semler BL; Department of Microbiology & Molecular Genetics and Center for Virus Research, University of California, Irvine, CA 92697, USA.

Viruses ; 12(2)2020 01 31.

Article in En | MEDLINE | ID: mdl-32023921

Subject(s)

DNA-Binding Proteins/genetics; Phosphoric Diester Hydrolases/genetics; Picornaviridae Infections/virology; Picornaviridae/genetics; CRISPR-Cas Systems; Cell Line; DNA-Binding Proteins/metabolism; Epithelial Cells/virology; Gene Knockout Techniques; Humans; Phosphoric Diester Hydrolases/metabolism; Picornaviridae/growth & development; Polyribosomes/immunology; RNA, Double-Stranded/genetics; RNA, Viral/genetics; Retina/cytology

Key words

RNA replication; TDP2 (tyrosyl DNA phosphodiesterase 2); VPg unlinkase; coxsackievirus; picornavirus; poliovirus; polysome analysis; retinal pigment epithelial cells (RPE cells); viral translation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Picornaviridae / Phosphoric Diester Hydrolases / Picornaviridae Infections / DNA-Binding Proteins Limits: Humans Language: En Journal: Viruses Year: 2020 Document type: Article Affiliation country: United States Country of publication: Switzerland

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