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Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4ß2 Receptor Antagonist for the Treatment of Depression.
Nirogi, Ramakrishna; Mohammed, Abdul Rasheed; Shinde, Anil K; Ravella, Srinivasa Rao; Bogaraju, Narsimha; Subramanian, Ramkumar; Mekala, Venkat Reddy; Palacharla, Raghava Choudary; Muddana, Nageswararao; Thentu, Jagadeesh Babu; Bhyrapuneni, Gopinadh; Abraham, Renny; Jasti, Venkat.
Affiliation
  • Nirogi R; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Mohammed AR; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Shinde AK; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Ravella SR; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Bogaraju N; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Subramanian R; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Mekala VR; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Palacharla RC; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Muddana N; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Thentu JB; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Bhyrapuneni G; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Abraham R; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
  • Jasti V; Discovery Research, Suven Life Sciences Ltd., Serene Chambers, Road-5, Avenue-7, Banjara Hills, Hyderabad 500 034, India.
J Med Chem ; 63(6): 2833-2853, 2020 03 26.
Article in En | MEDLINE | ID: mdl-32026697
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Receptors, Nicotinic / Nicotinic Antagonists / Antidepressive Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: India Country of publication: United States
Fulltext
Add to My VHL
Print
XML
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Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Receptors, Nicotinic / Nicotinic Antagonists / Antidepressive Agents Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2020 Document type: Article Affiliation country: India Country of publication: United States