Once-Daily Oxycodone Prolonged-Release Tablets Are Resistant to Alcohol-Induced Dose Dumping: Results From a Randomized Trial in Healthy Volunteers.

Burger, Nils; Fraser, Douglas; Maritz, Martina Alice; Faulkner, Janice; Rey, Helene

Burger, Nils; Fraser, Douglas; Maritz, Martina Alice; Faulkner, Janice; Rey, Helene.

Affiliation

Burger N; Develco Pharma Schweiz AG, Pratteln, Switzerland.
Fraser D; Develco Pharma Schweiz AG, Pratteln, Switzerland.
Maritz MA; Develco Pharma Schweiz AG, Pratteln, Switzerland.
Faulkner J; BioPharma Services Inc., Toronto, Ontario, Canada.
Rey H; Develco Pharma Schweiz AG, Pratteln, Switzerland.

Clin Transl Sci ; 13(3): 539-546, 2020 05.

Article in En | MEDLINE | ID: mdl-32027446

Subject(s)

Alcohol Drinking/adverse effects; Ethanol/adverse effects; Food-Drug Interactions; Oxycodone/administration & dosage; Administration, Oral; Adolescent; Adult; Alcohol Drinking/blood; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Preparations/administration & dosage; Delayed-Action Preparations/pharmacokinetics; Drug Administration Schedule; Ethanol/administration & dosage; Ethanol/pharmacokinetics; Fasting/blood; Female; Gastrointestinal Absorption/drug effects; Half-Life; Healthy Volunteers; Humans; Male; Middle Aged; Oxycodone/pharmacokinetics; Tablets; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxycodone / Alcohol Drinking / Food-Drug Interactions / Ethanol Type of study: Clinical_trials / Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Transl Sci Year: 2020 Document type: Article Affiliation country: Switzerland Country of publication: United States

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