Purpuric drug eruptions induced by EGFR tyrosine kinase inhibitors are associated with IQGAP1-mediated increase in vascular permeability.

Sheen, Yi-Shuan; Lin, Ming-Hsien; Tzeng, Wen-Chia; Chu, Chia-Yu

Sheen, Yi-Shuan; Lin, Ming-Hsien; Tzeng, Wen-Chia; Chu, Chia-Yu.

Affiliation

Sheen YS; Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Lin MH; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Tzeng WC; Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hisn-Chu, Taiwan.
Chu CY; Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

J Pathol ; 250(4): 452-463, 2020 04.

Article in En | MEDLINE | ID: mdl-32030757

Subject(s)

Capillary Permeability/drug effects; Endothelial Cells/metabolism; Genes, erbB-1/drug effects; Protein Kinase Inhibitors/pharmacology; ras GTPase-Activating Proteins/drug effects; Carcinoma, Non-Small-Cell Lung/metabolism; Carcinoma, Non-Small-Cell Lung/pathology; Cell Line, Tumor; Drug Eruptions/drug therapy; Drug Resistance, Neoplasm; Genes, erbB-1/genetics; Humans; Lung Neoplasms/drug therapy; Lung Neoplasms/pathology; Mutation/genetics; Quinazolines/pharmacology

Key words

IQGAP1; drug eruptions; endothelial cells; epidermal growth factor receptor tyrosine kinase inhibitor; erlotinib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capillary Permeability / Genes, erbB-1 / Ras GTPase-Activating Proteins / Endothelial Cells / Protein Kinase Inhibitors Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Pathol Year: 2020 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom

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