Efficacy of combined bland embolization and chemoembolization for huge (≥10 cm) hepatocellular carcinoma.
Minim Invasive Ther Allied Technol
; 30(4): 221-228, 2021 Aug.
Article
in En
| MEDLINE
| ID: mdl-32031474
ABSTRACT
INTRODUCTION:
To assess the efficacy of combined therapy involving bland transarterial embolization using gelatin sponge particles (bland GS-TAE) followed by transarterial chemoembolization using lipiodol mixed with anticancer agents and GS particles (Lip-TACE) to reduce the adverse events and increase the therapeutic effect of Lip-TACE in the treatment of huge (≥10 cm) hepatocellular carcinoma (HCC). MATERIAL ANDMETHODS:
Twenty-one consecutive patients with huge HCCs (≥10 cm in diameter) were enrolled in this study. First, bland GS-TAE was performed to reduce the tumor volume, and then Lip-TACE was performed to control the remaining tumor at intervals of around three weeks. Tumor response, survival, and adverse events of this combined therapy were assessed.RESULTS:
The tumor response was assessed three months after combined TACE, with complete response in 38.1% and partial response in 57.1% of cases. Severe adverse events were seen in two patients, acute cholecystitis and tumor rupture. The median survival time was 2.7 years, and the one-, two-, three-, and five-year overall survival rates were 76.2%, 66.7%, 42.9%, and 25.0%, respectively.CONCLUSION:
Combined therapy involving bland GS-TAE followed by Lip-TACE can be performed safety and may improve survival in patients with huge HCCs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chemoembolization, Therapeutic
/
Carcinoma, Hepatocellular
/
Liver Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Journal:
Minim Invasive Ther Allied Technol
Journal subject:
TERAPEUTICA
Year:
2021
Document type:
Article
Affiliation country:
Japan