The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.

Timm, Kerstin N; Tyler, Damian J

Timm, Kerstin N; Tyler, Damian J.

Affiliation

Timm KN; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK. kerstin.timm@dpag.ox.ac.uk.
Tyler DJ; Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.

Cardiovasc Drugs Ther ; 34(2): 255-269, 2020 04.

Article in En | MEDLINE | ID: mdl-32034646

Subject(s)

AMP-Activated Protein Kinases/metabolism; Antibiotics, Antineoplastic/adverse effects; Doxorubicin/adverse effects; Enzyme Activators/therapeutic use; Heart Diseases/prevention & control; Mitochondria, Heart/drug effects; Myocytes, Cardiac/drug effects; Aminoimidazole Carboxamide/analogs & derivatives; Aminoimidazole Carboxamide/therapeutic use; Animals; Caloric Restriction; Cardiotoxicity; Enzyme Activation; Exercise; Heart Diseases/chemically induced; Heart Diseases/enzymology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Metformin/pharmacology; Mitochondria, Heart/enzymology; Mitochondria, Heart/pathology; Myocytes, Cardiac/enzymology; Myocytes, Cardiac/pathology; Resveratrol/therapeutic use; Ribonucleotides/therapeutic use; Signal Transduction; Thiazolidinediones/therapeutic use

Key words

AICAR; AMPK; Cardiotoxicity; Doxorubicin; Metformin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Enzyme Activators / Myocytes, Cardiac / AMP-Activated Protein Kinases / Heart Diseases / Mitochondria, Heart / Antibiotics, Antineoplastic Limits: Animals / Humans Language: En Journal: Cardiovasc Drugs Ther Journal subject: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United States

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