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CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity.
Gutiérrez Rico, Evelyn Marie; Kikuchi, Aoi; Saito, Takahiro; Kumondai, Masaki; Hishinuma, Eiji; Kaneko, Akira; Chan, Chim Wai; Gitaka, Jesse; Nakayoshi, Tomoki; Oda, Akifumi; Saito, Sakae; Hirasawa, Noriyasu; Hiratsuka, Masahiro.
Affiliation
  • Gutiérrez Rico EM; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
  • Kikuchi A; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
  • Saito T; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
  • Kumondai M; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
  • Hishinuma E; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan; Tohoku Medical Megabank Organization,
  • Kaneko A; Department of Parasitology and Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Chan CW; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Gitaka J; Mount Kenya University, Thika, Kenya.
  • Nakayoshi T; Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan.
  • Oda A; Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan.
  • Saito S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8575, Japan.
  • Hirasawa N; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan; Department of Pharmaceutical Sciences
  • Hiratsuka M; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, 980-8575, Japan; Tohoku Medical Megabank Organization,
Drug Metab Pharmacokinet ; 35(1): 89-101, 2020 Feb.
Article in En | MEDLINE | ID: mdl-32037159
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP2D6 / Dextromethorphan / Alleles Type of study: Risk_factors_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2020 Document type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 CYP2D6 / Dextromethorphan / Alleles Type of study: Risk_factors_studies Limits: Humans Country/Region as subject: Asia Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2020 Document type: Article Affiliation country: Japan