Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci.

Djoric, Dusanka; Little, Jaime L; Kristich, Christopher J

Djoric, Dusanka; Little, Jaime L; Kristich, Christopher J.

Affiliation

Djoric D; Department of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Little JL; Department of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Kristich CJ; Department of Microbiology and Immunology, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA ckristich@mcw.edu.

Antimicrob Agents Chemother ; 64(4)2020 03 24.

Article in En | MEDLINE | ID: mdl-32041714

Subject(s)

Cephalosporin Resistance/physiology; Enterococcus faecalis/drug effects; Enterococcus faecium/drug effects; Penicillin-Binding Proteins/physiology; Acylation; Cross Infection/drug therapy; Cross Infection/microbiology; Electrophoresis, Polyacrylamide Gel; Enterococcus faecalis/metabolism; Enterococcus faecium/metabolism; Gastrointestinal Tract/microbiology; Humans; Immunoblotting; Inhibitory Concentration 50; Microscopy, Electron, Transmission; Penicillin-Binding Proteins/chemistry; Penicillin-Binding Proteins/metabolism; Peptidoglycan/biosynthesis

Key words

beta-lactam resistance; cephalosporins; enterococci; penicillin-binding proteins; peptidoglycan synthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterococcus faecium / Enterococcus faecalis / Cephalosporin Resistance / Penicillin-Binding Proteins Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2020 Document type: Article Affiliation country: United States Country of publication: United States

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