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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
Bruno, Peter M; Lu, Mengrou; Dennis, Kady A; Inam, Haider; Moore, Connor J; Sheehe, John; Elledge, Stephen J; Hemann, Michael T; Pritchard, Justin R.
Affiliation
  • Bruno PM; Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115.
  • Lu M; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115.
  • Dennis KA; Department of Genetics, Harvard Medical School, Boston, MA 02115.
  • Inam H; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.
  • Moore CJ; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.
  • Sheehe J; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.
  • Elledge SJ; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.
  • Hemann MT; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802.
  • Pritchard JR; Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115; selledge@genetics.med.harvard.edu hemann@mit.edu jrp94@psu.edu.
Proc Natl Acad Sci U S A ; 117(8): 4053-4060, 2020 02 25.
Article in En | MEDLINE | ID: mdl-32041867
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Survival / Benzothiazoles / Poly-ADP-Ribose Binding Proteins / Naphthyridines / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Survival / Benzothiazoles / Poly-ADP-Ribose Binding Proteins / Naphthyridines / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article