Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.

Farhat, Diana; Ghayad, Sandra E; Icard, Philippe; Le Romancer, Muriel; Hussein, Nader; Lincet, Hubert

Farhat, Diana; Ghayad, Sandra E; Icard, Philippe; Le Romancer, Muriel; Hussein, Nader; Lincet, Hubert.

Affiliation

Farhat D; Université Lyon 1, Lyon, France.
Ghayad SE; Inserm U1052, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France.
Icard P; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France.
Le Romancer M; Lebanese University, Faculty of Sciences, Cancer biology Stem Cells and Molecular Immunology, Hadath-Beirut, Lebanon.
Hussein N; Department of Biology, Faculty of Science II, Lebanese University, Fanar, Lebanon.
Lincet H; Normandie Univ, UNICAEN, CHU de Caen Normandie, Unité de recherche BioTICLA INSERM U 119, 14000, Caen, France.

Oncogene ; 39(17): 3604-3610, 2020 04.

Article in En | MEDLINE | ID: mdl-32060422

Subject(s)

Breast Neoplasms/metabolism; Cyclic AMP Response Element-Binding Protein/metabolism; Furin/metabolism; Neoplasm Proteins/metabolism; Oxidative Stress/drug effects; Receptor, IGF Type 1/metabolism; Thioctic Acid/pharmacology; Breast Neoplasms/drug therapy; Breast Neoplasms/pathology; Female; Humans; MCF-7 Cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Thioctic Acid / Receptor, IGF Type 1 / Cyclic AMP Response Element-Binding Protein / Oxidative Stress / Furin / Neoplasm Proteins Limits: Female / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2020 Document type: Article Affiliation country: France Country of publication: United kingdom

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