Corticosteroid eyedrops induced blepharoptosis and atrophy of levator muscle.
Graefes Arch Clin Exp Ophthalmol
; 258(5): 1081-1086, 2020 May.
Article
in En
| MEDLINE
| ID: mdl-32060728
ABSTRACT
PURPOSE:
The purpose of the study is to analyze the incidence, manifestations, and treatment of blepharoptosis caused by long-term use of corticosteroid eyedrops.METHODS:
Retrospective case series include 46 patients with a history of using corticosteroid eyedrops unilaterally for at least 2 months. The palpebral fissure, MRD1, and levator function were evaluated.RESULTS:
Among 46 patients, the differences of mean MRD1 (p < 0.0005), palpebral fissure height (p < 0.0005), and levator function (p = 0.003) between eyes with and without corticosteroid eyedrops application were significant. Ptosis existed in 40 out of 46 eyes with corticosteroid; the differences of the mean MRD1 (p < 0.0005) and palpebral fissure height (p = 0.001) between eyes with and without ptosis were significant. Nine patients underwent levator aponeurosis repair surgeries. Pathological examinations revealed mainly vascular fibers and few muscle fibers, as well as apoptosis of levator palpebrae muscle and Muller muscle.CONCLUSION:
Blepharoptosis is frequently observed after chronic corticosteroid eyedrops use in Chinese population.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blepharoptosis
/
Muscular Atrophy
/
Glucocorticoids
/
Oculomotor Muscles
Type of study:
Diagnostic_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Graefes Arch Clin Exp Ophthalmol
Year:
2020
Document type:
Article
Affiliation country:
China