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Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.
Omar, Abdelsattar M; Alswah, Mohamed; Ahmed, Hany E A; Bayoumi, Ashraf H; El-Gamal, Kamal M; El-Morsy, Ahmed; Ghiaty, Adel; Afifi, Tarek H; Sherbiny, Farag F; Mohammed, Adel Saad; Mansour, Baseem Awad.
Affiliation
  • Omar AM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Abdul-Aziz University, Jeddah, Saudi Arabia. Electronic address: asmansour@kau.edu.sa.
  • Alswah M; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
  • Ahmed HEA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.
  • Bayoumi AH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
  • El-Gamal KM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, Mansoura, Egypt.
  • El-Morsy A; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, The Islamic University in Najaf, Al-Najaf Al-Ashraf 54001, Iraq.
  • Ghiaty A; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
  • Afifi TH; Chemistry Department, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.
  • Sherbiny FF; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
  • Mohammed AS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
  • Mansour BA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Delta University for Science and Technology, Mansoura, Egypt.
Bioorg Chem ; 96: 103656, 2020 03.
Article in En | MEDLINE | ID: mdl-32062449
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinoxalines / Escherichia coli / Topoisomerase II Inhibitors / Folic Acid Antagonists / Anti-Bacterial Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinoxalines / Escherichia coli / Topoisomerase II Inhibitors / Folic Acid Antagonists / Anti-Bacterial Agents Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2020 Document type: Article Country of publication: United States