Interactions Between the Aging Gut Microbiome and Common Geriatric Giants: Polypharmacy, Frailty, and Dementia.
J Gerontol A Biol Sci Med Sci
; 76(6): 1019-1028, 2021 05 22.
Article
in En
| MEDLINE
| ID: mdl-32064521
ABSTRACT
The gut microbiome has pervasive bidirectional relationships with pharmacotherapy, chronic disease, and physical and cognitive function. We conducted a narrative review of the current literature to examine the relationships between the gut microbiome, medication use, sarcopenia and frailty, and cognitive impairment. Data from in vitro experiments, in vivo experiments in invertebrates and complex organisms, and humans indicate associations between the gut microbiome and geriatric syndromes. Better understanding of the direct and indirect roles of the microbiome may inform future prevention and management of geriatric syndromes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Polypharmacy
/
Dementia
/
Gastrointestinal Microbiome
/
Frailty
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Gerontol A Biol Sci Med Sci
Journal subject:
GERIATRIA
Year:
2021
Document type:
Article
Affiliation country:
Australia