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AC biosusceptometry and magnetic nanoparticles to assess doxorubicin-induced kidney injury in rats.
Prospero, Andre G; Fidelis-de-Oliveira, Patrícia; Soares, Guilherme A; Miranda, Milena F; Pinto, Leonardo A; Dos Santos, Daniela C; Silva, Vanessa Dos S; Zufelato, Nicholas; Bakuzis, Andris F; Miranda, José Ra.
Affiliation
  • Prospero AG; Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
  • Fidelis-de-Oliveira P; Departamento de Fisiologia, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
  • Soares GA; Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
  • Miranda MF; Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
  • Pinto LA; Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
  • Dos Santos DC; Departamento de Patologia, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-687, Brazil.
  • Silva VDS; Departamento de Clínica Médica, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-687, Brazil.
  • Zufelato N; Instituto de Física, Universidade Federal de Goiás, Alameda Palmeiras St, Goiânia, 74690-900, Brazil.
  • Bakuzis AF; Instituto de Física, Universidade Federal de Goiás, Alameda Palmeiras St, Goiânia, 74690-900, Brazil.
  • Miranda JR; Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
Nanomedicine (Lond) ; 15(5): 511-525, 2020 02.
Article in En | MEDLINE | ID: mdl-32077357
Aim: This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys. Materials & methods: We used the ACB to detect the MNP kidney perfusion in vivo. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution. Results: We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved. Conclusion: This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Magnetite Nanoparticles / Kidney Limits: Animals Language: En Journal: Nanomedicine (Lond) Year: 2020 Document type: Article Affiliation country: Brazil Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Magnetite Nanoparticles / Kidney Limits: Animals Language: En Journal: Nanomedicine (Lond) Year: 2020 Document type: Article Affiliation country: Brazil Country of publication: United kingdom