Prostaglandin E<sub>2</sub>, Produced by Mast Cells in Colon Tissues From Patients With Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice.

Grabauskas, Gintautas; Wu, Xiaoyin; Gao, Jun; Li, Ji-Yao; Turgeon, Danielle Kim; Owyang, Chung

Prostaglandin E₂, Produced by Mast Cells in Colon Tissues From Patients With Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice.

Grabauskas, Gintautas; Wu, Xiaoyin; Gao, Jun; Li, Ji-Yao; Turgeon, Danielle Kim; Owyang, Chung.

Affiliation

Grabauskas G; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Wu X; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Gao J; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Li JY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Turgeon DK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Owyang C; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. Electronic address: cowyang@med.umich.edu.

Gastroenterology ; 158(8): 2195-2207.e6, 2020 06.

Article in En | MEDLINE | ID: mdl-32084424

Subject(s)

Colon/metabolism; Dinoprostone/metabolism; Intestinal Mucosa/metabolism; Irritable Bowel Syndrome/complications; Mast Cells/metabolism; Tissue Extracts/metabolism; Abdominal Pain/etiology; Abdominal Pain/metabolism; Abdominal Pain/physiopathology; Adult; Animals; Case-Control Studies; Cells, Cultured; Colon/innervation; Cyclooxygenase 2/deficiency; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Diarrhea/etiology; Diarrhea/metabolism; Diarrhea/physiopathology; Female; Humans; Hyperalgesia/etiology; Hyperalgesia/metabolism; Hyperalgesia/physiopathology; Intestinal Mucosa/innervation; Irritable Bowel Syndrome/metabolism; Irritable Bowel Syndrome/physiopathology; Male; Mast Cells/pathology; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Rats, Wistar; Sensory Receptor Cells/metabolism; Tissue Extracts/administration & dosage

Key words

Abdominal Pain; Dorsal Root Ganglia; Inflammation; Tryptase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tissue Extracts / Dinoprostone / Colon / Irritable Bowel Syndrome / Intestinal Mucosa / Mast Cells Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Gastroenterology Year: 2020 Document type: Article

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