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Antiretroviral therapy alone versus antiretroviral therapy with a kick and kill approach, on measures of the HIV reservoir in participants with recent HIV infection (the RIVER trial): a phase 2, randomised trial.
Fidler, Sarah; Stöhr, Wolfgang; Pace, Matt; Dorrell, Lucy; Lever, Andrew; Pett, Sarah; Kinloch-de Loes, Sabine; Fox, Julie; Clarke, Amanda; Nelson, Mark; Thornhill, John; Khan, Maryam; Fun, Axel; Bandara, Mikaila; Kelly, Damian; Kopycinski, Jakub; Hanke, Tomás; Yang, Hongbing; Bennett, Rachel; Johnson, Margaret; Howell, Bonnie; Barnard, Richard; Wu, Guoxin; Kaye, Steve; Wills, Mark; Babiker, Abdel; Frater, John.
Affiliation
  • Fidler S; Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, London, UK. Electronic address: s.fidler@imperial.ac.uk.
  • Stöhr W; Medical Research Council Clinical Trials Unit, University College London, London, UK.
  • Pace M; Nuffield Department of Medicine, Oxford University, UK; Nuffield Department of Medicine Oxford Martin School, Oxford, UK.
  • Dorrell L; Nuffield Department of Medicine, Oxford University, UK; Nuffield Department of Medicine, Oxford NIHR Biomedical Research Centre, Oxford, UK.
  • Lever A; Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Pett S; Medical Research Council Clinical Trials Unit, University College London, London, UK; Institute for Global Health, University College London, London, UK; Mortimer Market Centre, London, UK.
  • Kinloch-de Loes S; Department of Infection and Immunity, Royal Free Hospital, London, UK; University College London, London, UK.
  • Fox J; Department of Genitourinary Medicine and Infectious Disease, Guys and St Thomas' NHS Trust, London, UK; Department of Genitourinary Medicine and Infectious Disease, NIHR Biomedical Research Centre, Kings College London, London, UK.
  • Clarke A; Elton John Centre, Brighton, UK; Department of HIV and Sexual Health, Sussex University Hospital, Brighton, UK; Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
  • Nelson M; Chelsea and Westminster Hospital, Department of HIV Medicine, Imperial College London London, UK.
  • Thornhill J; Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, London, UK.
  • Khan M; Department of Infectious Disease, Imperial College London, London, UK; NIHR Imperial Biomedical Research Centre, London, UK.
  • Fun A; Department of Medicine, University of Cambridge, Cambridge, UK.
  • Bandara M; University of Cambridge, Cambridge, UK.
  • Kelly D; Patient Advocacy Alliance, Manchester, UK.
  • Kopycinski J; Nuffield Department of Medicine, Oxford University, UK; Nuffield Department of Medicine, Oxford NIHR Biomedical Research Centre, Oxford, UK.
  • Hanke T; Nuffield Department of Medicine, Oxford University, UK; International Research Center for Medical Sciences, Kumamoto University, Japan.
  • Yang H; Nuffield Department of Medicine, Oxford University, UK; Nuffield Department of Medicine, Oxford NIHR Biomedical Research Centre, Oxford, UK.
  • Bennett R; Medical Research Council Clinical Trials Unit, University College London, London, UK.
  • Johnson M; Department of HIV Medicine, Royal Free Hospital, London, UK.
  • Howell B; Department of Infectious Disease and Vaccines, Merck and Co, West Point, PA, USA.
  • Barnard R; Global Regulatory Affairs and Clinical Safety, Merck and Co, North Wales, PA, USA.
  • Wu G; Department of Infectious Disease and Vaccines, Merck and Co, West Point, PA, USA.
  • Kaye S; Department of Infectious Disease, Imperial College London, London, UK.
  • Wills M; Department of Medicine, University of Cambridge, Cambridge, UK.
  • Babiker A; Medical Research Council Clinical Trials Unit, University College London, London, UK.
  • Frater J; Nuffield Department of Medicine, Oxford University, UK; Nuffield Department of Medicine, Oxford NIHR Biomedical Research Centre, Oxford, UK. Electronic address: john.frater@ndm.ox.ac.uk.
Lancet ; 395(10227): 888-898, 2020 03 14.
Article in En | MEDLINE | ID: mdl-32085823
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Reservoirs / HIV Infections / AIDS Vaccines / Anti-Retroviral Agents / Histone Deacetylase Inhibitors / Vorinostat Type of study: Clinical_trials Limits: Adult / Humans / Male Language: En Journal: Lancet Year: 2020 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Reservoirs / HIV Infections / AIDS Vaccines / Anti-Retroviral Agents / Histone Deacetylase Inhibitors / Vorinostat Type of study: Clinical_trials Limits: Adult / Humans / Male Language: En Journal: Lancet Year: 2020 Document type: Article Country of publication: United kingdom