Thorough QT/QTc Study Shows That a Novel 5-HT<sub>4</sub> Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation.

Hamatani, Tatsuto; Noda, Naoto; Takagaki, Takeshi; Yodo, Yasuhide; Kawai, Hirotaka; Kakuyama, Hiroyoshi; Kaji, Yoshikazu; Fujio, Yasushi

Thorough QT/QTc Study Shows That a Novel 5-HT₄ Receptor Partial Agonist Minesapride Has No Effect on QT Prolongation.

Hamatani, Tatsuto; Noda, Naoto; Takagaki, Takeshi; Yodo, Yasuhide; Kawai, Hirotaka; Kakuyama, Hiroyoshi; Kaji, Yoshikazu; Fujio, Yasushi.

Affiliation

Hamatani T; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Noda N; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Takagaki T; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Yodo Y; Data Science, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Kawai H; Clinical Operation, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Kakuyama H; Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan.
Kaji Y; Hakata Clinic, SOUSEIKAI, Fukuoka, Japan.
Fujio Y; Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan.

Clin Pharmacol Drug Dev ; 9(8): 938-951, 2020 11.

Article in En | MEDLINE | ID: mdl-32087003

Subject(s)

Irritable Bowel Syndrome/drug therapy; Long QT Syndrome/chemically induced; Morpholines/adverse effects; Piperidines/adverse effects; Serotonin 5-HT4 Receptor Agonists/adverse effects; Administration, Oral; Adult; Anti-Bacterial Agents/administration & dosage; Arrhythmias, Cardiac/chemically induced; Asian People/ethnology; Benzamides/pharmacokinetics; Case-Control Studies; Cisapride/administration & dosage; Cisapride/adverse effects; Cisapride/therapeutic use; Cross-Over Studies; Double-Blind Method; Electrocardiography/methods; Electrocardiography/statistics & numerical data; Female; Humans; Indoles/administration & dosage; Indoles/adverse effects; Indoles/therapeutic use; Male; Morpholines/administration & dosage; Morpholines/pharmacokinetics; Moxifloxacin/administration & dosage; Piperidines/administration & dosage; Piperidines/pharmacokinetics; Placebos/administration & dosage; Serotonin 5-HT4 Receptor Agonists/administration & dosage; Serotonin 5-HT4 Receptor Agonists/pharmacokinetics; Serotonin Receptor Agonists/administration & dosage; Serotonin Receptor Agonists/adverse effects; Serotonin Receptor Agonists/therapeutic use

Key words

5-HT4 receptor agonist; DSP-6952; QT; benzamide; minesapride

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Long QT Syndrome / Morpholines / Irritable Bowel Syndrome / Serotonin 5-HT4 Receptor Agonists Type of study: Clinical_trials / Observational_studies / Risk_factors_studies Language: En Journal: Clin Pharmacol Drug Dev Year: 2020 Document type: Article Affiliation country: Japan Country of publication: United States

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