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Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α.
Tezera, Liku B; Bielecka, Magdalena K; Ogongo, Paul; Walker, Naomi F; Ellis, Matthew; Garay-Baquero, Diana J; Thomas, Kristian; Reichmann, Michaela T; Johnston, David A; Wilkinson, Katalin Andrea; Ahmed, Mohamed; Jogai, Sanjay; Jayasinghe, Suwan N; Wilkinson, Robert J; Mansour, Salah; Thomas, Gareth J; Ottensmeier, Christian H; Leslie, Alasdair; Elkington, Paul T.
Affiliation
  • Tezera LB; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Bielecka MK; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
  • Ogongo P; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Walker NF; Africa Health Research Institute, KwaZulu Natal, South Africa.
  • Ellis M; Department of Tropical and Infectious Diseases, Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya.
  • Garay-Baquero DJ; Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Thomas K; TB Centre and Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • Reichmann MT; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Johnston DA; NIHR Biomedical Research Centre, School of Cancer Sciences, University of Southampton, Southampton, United Kingdom.
  • Wilkinson KA; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Ahmed M; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.
  • Jogai S; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Jayasinghe SN; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Wilkinson RJ; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Mansour S; The Francis Crick Institute, London, United Kingdom.
  • Thomas GJ; Africa Health Research Institute, KwaZulu Natal, South Africa.
  • Ottensmeier CH; NIHR Biomedical Research Centre, School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
  • Leslie A; BioPhysics Group, Department of Mechanical Engineering, University College London, London, United Kingdom.
  • Elkington PT; The Francis Crick Institute, London, United Kingdom.
Elife ; 92020 02 24.
Article in En | MEDLINE | ID: mdl-32091388
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Latent Tuberculosis / Programmed Cell Death 1 Receptor / Immunotherapy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Elife Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Latent Tuberculosis / Programmed Cell Death 1 Receptor / Immunotherapy Type of study: Prognostic_studies Limits: Humans Language: En Journal: Elife Year: 2020 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom