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Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy.
Chuang, Shih-Hsien; Lee, Ying-Shuan E; Huang, Lynn Y L; Chen, Chi-Kuan; Lai, Chun-Liang; Lin, Yu-Hsiang; Yang, Ju-Ying; Yang, Sheng-Chuan; Chang, Lien-Hsiang; Chen, Ching-Hui; Liu, Chia-Wei; Lin, Her-Sheng; Lee, Yi-Ru; Huang, Kuan Pin; Fu, Kuo Chu; Jen, Hsueh-Min; Lai, Jun-Yu; Jian, Pei-Shiou; Wang, Yu-Chuan; Hsueh, Wen-Yun; Tsai, Pei-Yi; Hong, Wan-Hua; Chang, Chia-Chi; Wu, Diana Zc; Wu, Jinn; Chen, Meng-Hsin; Yu, Kuo-Ming; Chern, Ching Yuh; Chang, Jia-Ming; Lau, Johnson Y N; Huang, Jiann-Jyh.
Affiliation
  • Chuang SH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Lee YE; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Huang LYL; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.
  • Chen CK; Genomics Research Center, Academia Sinica, Taipei City, Taiwan.
  • Lai CL; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Lin YH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Yang JY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Yang SC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Chang LH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Chen CH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Liu CW; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Lin HS; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Lee YR; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Huang KP; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Fu KC; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Jen HM; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Lai JY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.
  • Jian PS; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.
  • Wang YC; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.
  • Hsueh WY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.
  • Tsai PY; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Hong WH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Chang CC; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.
  • Wu DZ; Xenobiotic Laboratories, Inc., Plainsboro, NJ, USA.
  • Wu J; Xenobiotic Laboratories, Inc., Plainsboro, NJ, USA.
  • Chen MH; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Yu KM; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.
  • Chern CY; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan.
  • Chang JM; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan.
  • Lau JYN; Taivex Therapeutics Corporation, 2nd Floor, Dongxing Rd., Songshan Dist., Taipei City, 10511, Taiwan.
  • Huang JJ; Development Center for Biotechnology, National Biotechnology Research Park, Taipei City, 11571, Taiwan; Department of Applied Chemistry, National Chiayi University, No. 300, Syuefu Rd., Chiayi City, 60004, Taiwan. Electronic address: lukehuang@mail.ncyu.edu.tw.
Eur J Med Chem ; 191: 112118, 2020 Apr 01.
Article in En | MEDLINE | ID: mdl-32113126
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytoskeletal Proteins / Protein Kinase Inhibitors / Drug Discovery / NIMA-Related Kinases / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Affiliation country: Taiwan Country of publication: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytoskeletal Proteins / Protein Kinase Inhibitors / Drug Discovery / NIMA-Related Kinases / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Affiliation country: Taiwan Country of publication: France