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Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs.
Siméon, Ségolène; Brotzmann, Katharina; Fisher, Ciaran; Gardner, Iain; Silvester, Steve; Maclennan, Richard; Walker, Paul; Braunbeck, Thomas; Bois, Frederic Y.
Affiliation
  • Siméon S; INERIS, METO Unit, Parc ALATA BP2, Verneuil en Halatte, France.
  • Brotzmann K; University of Heidelberg, Aquatic Ecology and Toxicology, Centre for Organismal Studies (COS), Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany.
  • Fisher C; CERTARA UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, United Kingdom.
  • Gardner I; CERTARA UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, United Kingdom.
  • Silvester S; Cyprotex Discovery Ltd., No. 24 Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom.
  • Maclennan R; Cyprotex Discovery Ltd., No. 24 Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom.
  • Walker P; Cyprotex Discovery Ltd., No. 24 Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, United Kingdom.
  • Braunbeck T; University of Heidelberg, Aquatic Ecology and Toxicology, Centre for Organismal Studies (COS), Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany.
  • Bois FY; CERTARA UK Limited, Simcyp Division, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, United Kingdom. Electronic address: frederic.bois@certara.com.
Reprod Toxicol ; 93: 219-229, 2020 04.
Article in En | MEDLINE | ID: mdl-32114065
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / Valproic Acid / Embryo, Nonmammalian / Models, Biological / Anticonvulsants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Reprod Toxicol Journal subject: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Year: 2020 Document type: Article Affiliation country: France Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / Valproic Acid / Embryo, Nonmammalian / Models, Biological / Anticonvulsants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Reprod Toxicol Journal subject: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Year: 2020 Document type: Article Affiliation country: France Country of publication: United States