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The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6.
Denomme, Nicholas; Lukowski, April L; Hull, Jacob M; Jameson, Margaret B; Bouza, Alexandra A; Narayan, Alison R H; Isom, Lori L.
Affiliation
  • Denomme N; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Center for Consciousness Science, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Lukowski AL; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Hull JM; Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Jameson MB; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Molecular and Cellular Pharmacology Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705 United States.
  • Bouza AA; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Narayan ARH; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, 48109 United States.
  • Isom LL; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, 48109 United States; Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan, 48109 United
Neurosci Lett ; 724: 134853, 2020 04 17.
Article in En | MEDLINE | ID: mdl-32114117
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrodotoxin / NAV1.1 Voltage-Gated Sodium Channel / NAV1.6 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers Limits: Animals / Female / Humans / Male Language: En Journal: Neurosci Lett Year: 2020 Document type: Article Country of publication: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrodotoxin / NAV1.1 Voltage-Gated Sodium Channel / NAV1.6 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers Limits: Animals / Female / Humans / Male Language: En Journal: Neurosci Lett Year: 2020 Document type: Article Country of publication: Ireland