Placental dysfunction: health status, nutritional status and mineral profile of a mother-child pair.

ABSTRACT

OBJECTIVE: The aim: the analysis of the PD, pregnancy, the labor, the research on peculiarities of the development and health status of breast-fed children, who are born to mothers with PD, by means of analyzing the mother-child pair's nutritional status and mineral homeostasis. PATIENTS AND METHODS: Materials and methods: At the 1 stage, an analysis of the PD frequency, the pregnancy, the labor was conducted during 5 years. At the 2 stage, 188 mother-child pairs were examined 84.04% women had PD and 15.96% didn't have it. The research included the analysis of the anamnestic data, maternal nutritional status, general clinical study, assessment of the physical, psychomotor level of the child's development, study of the elemental profile. RESULTS: Results: High frequency of complications in pregnancy and labor was observed in cases when women had PD, due to the imbalance in the "mother-placenta-fetus" system. The results' analysis showed an increased level of Zn (1.437%), K (10.147%), and Ca (83.900%) in hair; an increased level of K (82.818%), Cr (0.274%), and Na (3.611%) in breast milk of women with PD. Children born to mothers with PD had a significantly increased level of Cr (0.92%), S (0.578%) and P (0.169%), Na (0.107%), Ca (56.041%), and Zn (7.149%). CONCLUSION: Conclusions: PD has a negative impact on the pregnancy and labor and may be one of the factors causing the mineral imbalance of breast-fed infant.