Your browser doesn't support javascript.
loading
Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving.
Chukwueke, Chidera C; Kowalczyk, William J; Di Ciano, Patricia; Gendy, Marie; Taylor, Richard; Heishman, Stephen J; Le Foll, Bernard.
Affiliation
  • Chukwueke CC; Translational Addiction Research Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
  • Kowalczyk WJ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Di Ciano P; National Institute on Drug Abuse, Intramural Research Program, Baltimore, United States of America.
  • Gendy M; Department of Psychology, Hartwick College, Oneonta, New York, United States of America.
  • Taylor R; Translational Addiction Research Laboratory, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
  • Heishman SJ; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Le Foll B; CAMH, Campbell Family Mental Health Research Institute, Toronto, ON, Canada.
Sci Rep ; 10(1): 4085, 2020 03 05.
Article in En | MEDLINE | ID: mdl-32139730
Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study investigated the relationship between the Ser9Gly variant and measures of both nicotine reinforcement and cue-elicited craving. Phenotypes of smoking behaviors were assessed in genetically grouped (Glycine vs. No Glycine carriers) current smokers (n = 104, ≥ 10 cigarettes per day). Laboratory measures included a forced choice session (to measure reinforcement of nicotine containing vs. denicotinized cigarettes), and a cue-reactivity session (to measure smoking cues vs. neutral cues elicited craving). The forced choice procedure revealed that subjective ratings were significantly higher in response to nicotinized compared to denicotinized cigarettes; however the Ser9Gly variant did not influence this effect. By comparison, smoking cues elicited greater craving over time compared to neutral cues, and Glycine carriers of the Ser9Gly D3R variant seem to experience a significant blunted cue-elicited craving effect. Results support D3R involvement in nicotine cue reactivity. However, more research is needed to reveal how this gene variant modulates various aspects of nicotine dependence.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Reinforcement, Psychology / Tobacco Use Disorder / Smoking / Cues / Receptors, Dopamine D3 / Craving Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: America do norte Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Canada Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Reinforcement, Psychology / Tobacco Use Disorder / Smoking / Cues / Receptors, Dopamine D3 / Craving Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: America do norte Language: En Journal: Sci Rep Year: 2020 Document type: Article Affiliation country: Canada Country of publication: United kingdom