Formation, interpretation, and regulation of the Drosophila Dorsal/NF-κB gradient.
Curr Top Dev Biol
; 137: 143-191, 2020.
Article
in En
| MEDLINE
| ID: mdl-32143742
ABSTRACT
The morphogen gradient of the transcription factor Dorsal in the early Drosophila embryo has become one of the most widely studied tissue patterning systems. Dorsal is a Drosophila homolog of mammalian NF-κB and patterns the dorsal-ventral axis of the blastoderm embryo into several tissue types by spatially regulating upwards of 100 zygotic genes. Recent studies using fluorescence microscopy and live imaging have quantified the Dorsal gradient and its target genes, which has paved the way for mechanistic modeling of the gradient. In this review, we describe the mechanisms behind the initiation of the Dorsal gradient and its regulation of target genes. The main focus of the review is a discussion of quantitative and computational studies of the Dl gradient system, including regulation of the Dl gradient. We conclude with a discussion of potential future directions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphoproteins
/
Transcription Factors
/
Nuclear Proteins
/
NF-kappa B
/
Gene Expression Regulation, Developmental
/
Computational Biology
/
Body Patterning
/
Drosophila Proteins
/
Drosophila melanogaster
/
Embryo, Nonmammalian
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Curr Top Dev Biol
Year:
2020
Document type:
Article
Affiliation country:
United States