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Cadinane-type sesquiterpenes from the resinous exudates of Commiphora myrrha and their anti-Alzheimer's disease bioactivities.
Yu, Yi-Fan; Liu, Ying-Hong; Chen, Xiao-Han; Zhi, De-Juan; Qi, Feng-Ming; Zhang, Zong-Ping; Li, Yue-Qian; Zhang, Zhan-Xin; Fei, Dong-Qing.
Affiliation
  • Yu YF; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Liu YH; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Chen XH; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Zhi DJ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Qi FM; State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Zhang ZP; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Li YQ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China.
  • Zhang ZX; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: zhangzhx@lzu.edu.cn.
  • Fei DQ; School of Pharmacy, Lanzhou University, Lanzhou 730000, People's Republic of China. Electronic address: feidq@lzu.edu.cn.
Fitoterapia ; 142: 104536, 2020 Apr.
Article in En | MEDLINE | ID: mdl-32145310
ABSTRACT
Commiphoins A-C (1-3), three new cadinane-type sesquiterpenes, together with two known cadinane-type sesquiterpenes (4 and 5) were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were established on the basis of comprehensive spectroscopic methods, including HRESIMS, 1D and 2D NMR analyses. Compounds 1 and 3-5 were screened for anti-Alzheimer's disease (AD) activities using the AD pathological model in Caenorhabditis elegans. The results showed that they all had significant anti-AD activities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Commiphora / Alzheimer Disease / Polycyclic Sesquiterpenes Limits: Animals Language: En Journal: Fitoterapia Year: 2020 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Commiphora / Alzheimer Disease / Polycyclic Sesquiterpenes Limits: Animals Language: En Journal: Fitoterapia Year: 2020 Document type: Article