Your browser doesn't support javascript.
loading
In vitro activity of isavuconazole against three species of Acanthamoeba.
Brunet, K; Eestermans, R; Rodier, M-H; Cateau, E.
Affiliation
  • Brunet K; Laboratoire de parasitologie et mycologie médicale, CHU de Poitiers, bâtiment UBM, 2(e) étage, 2, rue de la Milétrie, 86021 Poitiers, France; Inserm U1070, université de Poitiers, Poitiers, France. Electronic address: kevin.brunet@univ-poitiers.fr.
  • Eestermans R; Laboratoire de parasitologie et mycologie médicale, CHU de Poitiers, bâtiment UBM, 2(e) étage, 2, rue de la Milétrie, 86021 Poitiers, France.
  • Rodier MH; Laboratoire de parasitologie et mycologie médicale, CHU de Poitiers, bâtiment UBM, 2(e) étage, 2, rue de la Milétrie, 86021 Poitiers, France; UMR CNRS 7267, écologie et biologie des interactions, équipe microbiologie de l'eau, université de Poitiers, Poitiers, France.
  • Cateau E; Laboratoire de parasitologie et mycologie médicale, CHU de Poitiers, bâtiment UBM, 2(e) étage, 2, rue de la Milétrie, 86021 Poitiers, France; UMR CNRS 7267, écologie et biologie des interactions, équipe microbiologie de l'eau, université de Poitiers, Poitiers, France.
J Fr Ophtalmol ; 43(4): 330-333, 2020 Apr.
Article in En | MEDLINE | ID: mdl-32151474
ABSTRACT
Acanthamoeba keratitis due to a genus of free-living amoebae is a severe corneal infection. Treatment of this disease is based on the combined use of antiseptics and other drugs, including azoles. We tested isavuconazole, the latest marketed azole, in vitro, against A. castellanii, A. lenticulata and A. hatchetti. Our results show that isavuconazole presents slight amoebistatic activity against A. castellanii trophozoites but no cysticidal activity. Isavuconazole could be used only in association for management of AK due to A. castellanii.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Triazoles / Acanthamoeba / Acanthamoeba Keratitis / Nitriles Limits: Animals / Humans Language: En Journal: J Fr Ophtalmol Year: 2020 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Triazoles / Acanthamoeba / Acanthamoeba Keratitis / Nitriles Limits: Animals / Humans Language: En Journal: J Fr Ophtalmol Year: 2020 Document type: Article