The efficacy and limitation of lumboperitoneal shunt in normal pressure hydrocephalus.
Clin Neurol Neurosurg
; 193: 105748, 2020 06.
Article
in En
| MEDLINE
| ID: mdl-32155527
ABSTRACT
OBJECTIVE:
To investigate whether the efficacy of the lumbar-peritoneal (LP) shunt is sustainable, we measured the outcomes of patients with idiopathic NPH (iNPH) preoperatively and postoperatively. PATIENTS ANDMETHODS:
We retrospective reviewed records of 58 patients with iNPH from 2013 to 2015. Exclusion of 7 patients expired, 1 patient shunt infection, and 8 patients was loss of follow-up. In the remaining 42 patients, the mood, talking response, movement, attention, recalling memory, and mini-mental state examination (MMSE), representing patient outcomes, were measured. All of whom were follow-up for 3 years.RESULTS:
Mood (1.91⯱â¯0.30), talking response (1.98⯱â¯0.15), movement (1.71⯱â¯0.51), attention (1.95⯱â¯0.22), and recalling memory (1.86⯱â¯0.35) were significantly improved after surgery (1 week;pâ¯<⯠0.0001). However, the indicators significantly declined after 3 years (mood 0.31 ± 0.52, talking response 0.50 ± 0.59, movement 0.17 ± 0.38, attention 0.40 ± 0.59, recalling memory 0.21 ± 0.42). The MMSE was also significantly improved after 3 months of surgery (17.9 5 ± 2.80 vs. 25.02 ± 3.36; pâ¯<⯠0.0001). However, it declined after 3 years (17.83 ± 3.66; p = 0.83).CONCLUSION:
The iNPH is considered potentially reversible. Our data supported that the LP shunt was efficient in the short term. However, the neurological degeneration was still progressive.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peritoneovenous Shunt
/
Hydrocephalus, Normal Pressure
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Neurol Neurosurg
Year:
2020
Document type:
Article