mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.
Science
; 367(6483): 1255-1260, 2020 03 13.
Article
in En
| MEDLINE
| ID: mdl-32165587
ABSTRACT
T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can cause disease, T cell quiescence must be preserved. Despite its importance, the mechanisms underlying the "quiescent state" remain elusive. Here, we identify BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence. BTG1/2-deficient T cells show an increased proliferation and spontaneous activation due to a global increase in messenger RNA (mRNA) abundance, which reduces the threshold to activation. BTG1/2 deficiency leads to an increase in polyadenylate tail length, resulting in a greater mRNA half-life. Thus, BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence. Our study reveals a key mechanism underlying T cell quiescence and suggests that low mRNA abundance is a crucial feature for maintaining quiescence.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA, Messenger
/
Lymphocyte Activation
/
T-Lymphocytes
/
Immediate-Early Proteins
/
RNA Stability
/
Tumor Suppressor Proteins
/
Neoplasm Proteins
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Science
Year:
2020
Document type:
Article
Affiliation country:
United States